Gabriela Martinez
WORK EXPERIENCE AND EDUCATION
10/18-on going UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Medicine. Neurology and Neurosurgery Department, Adjunct Professor
12/17-on going UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Medicine.
Senior Researcher
11/19-on going BIOMEDICAL NEUROSCIENCE INSTITUTE SANTIAGO, CHILE
University of Chile.
Director of Education and Outreach
04/16-11/17 MAYOR UNIVERSITY SANTIAGO, CHILE
Center of Integrative Biology
Postdoctoral Research Fellowship.
06/17-06/17 BUCK INSTITUTE NOVATO, USA
Buck Institute of Research on aging
Internship of Post doc.
11/14-04/16 PONTIFICAL CATHOLIC UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Biological Sciences
Postdoctoral Research Fellowship.
04/13-09/13 CORNELL UNIVERSITY NEW YORK, USA
Weill Cornell Medical College
Internship of Ph.D.
09/11-03/12 HARVARD UNIVERSITY BOSTON, USA
Harvard School of Public Health
Internship of Ph.D.
03/09-03/14 UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Medicine.
PhD. in Biomedical Sciences.
03/08-03/09 UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Medicine.
Research Assistant.
01/06-03/08 PONTIFICAL CATHOLIC UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Biological Sciences
Research Associate.
03/01-01/06 PONTIFICAL CATHOLIC UNIVERSITY OF CHILE SANTIAGO, CHILE
Faculty of Biological Sciences
Bachelor in Biological Sciences.
IMPACT
Total citations (ISI Web of Knowlegde): 762
H-Factor = 10
SELECTED PUBLICATIONS, REVIEWS AND BOOK CHAPTERS
1. Martínez G, et al. ER Proteostasis Control of Neuronal Physiology and Synaptic Function. Trends in Neuroscience. 2018
2. Martínez G, et al. ER proteostasis impairment. Aging Cell. 2017
3. Martínez G, et al. Commentary: XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Front Aging Neurosci. 2016
4. Valenzuela V., Martínez G, et al. Gene therapy to target ER stress in brain diseases. Brain Research. 2016
5. Martínez G, et al. The UPR transcription factor XBP1 regulates memory formation. Cell Reports.2016
6. Oñate M, Catenaccio A, Martínez G, et al. Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Scientific Reports. 2016.
7. Mardones P, Martínez G, Hetz C. Control of systemic proteostasis by the nervous system. Trends in Cell Biology. 2014
8. Duran-Aniotz C, Martínez G, Hetz C. Memory loss in Alzheimer´s disease: Are the alterations in the UPR network involved in the cognitive impairment?. Front Aging Neurosci. 2014
9. Martínez G, Hetz C. Cell-nonautonomous control of the UPR. EMBO reports. 2012
10. Rojas-Rivera D, Armisén R, Colombo A, Eguiguren A, Martínez G, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell death and differentiation. 2012
11. Klein A, Mosqueira M, Martínez G, et al. Lack of activation of the unfolded protein response in mouse and cellular models of Niemann-Pick type C disease. Neurodegener Dis. 2011
12. Hetz C, Thielen P, Matus S, M Nassif, Court F, Cuervo AM, Martinez G., et al. XBP-1 deficiency in neurons protects against amyotrophic lateral sclerosis by increasing autophagy. Genes & Dev. (Cover illustration) 2009. Comment Genes Dev. 2009
13. Galleguillos D, Matus S, Valenzuela V, Valdés P, Martínez A, Nassif M, Torres M, Martínez G, Hetz C. Targeting endoplasmic reticulum stress pathways to treat neurological disorders associated with protein misfolding. E-Book published by Bentham Science. 2009
14. Leisewitz A, Urrutia C, Martínez G, et al. A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. J Cell Physiol. 2008
15. Fuenzalida K, Quintanilla R, Ramos P, Piderit D, Fuentealba RA, Martínez G, et al. Peroxisome Proliferator-activated Receptor {gamma} Up-regulates the Bcl-2 Anti-apoptotic Protein in Neurons and Induces Mitochondrial Stabilization and Protection against Oxidative Stress and Apoptosis”. J Biol Chem. 2007
INTELECTUAL PROPERTY FILES: PATENTS
Claudio Hetz and Gabriela Martinez, application number 3590-2014 (2014). AAV-XBP1s as an
agent to increase memory performance. Submitted 30/12/2014. National Institute of Intellectual
Property (INAPI), Chile. PENDING.
SELECTED HONORs, AWARDS and GRANTS
2017 Annual Prize L’Oréal-UNESCO For Women in Science. Qualified in the second place. Chile.
2015 ROLE OF ER STRESS ON THE CELL AUTONOMOUS OR NON-AUTONOMOUS EFFECT TRIGGERED BY WALLERIAN DEGENERATION. FONDECYT Postdoctoral Fellowship, Principal investigator. Qualified in the first place. Chile.
2014 Annual Prize for the best doctoral PhD thesis Dr. Federico Leighton 2014. Selected finalist by the comitee of Society of Cellular Biology of Chile.
2012 CONICYT fellowship for meetings or courses abroad for PhD students. Chile (ZING CONFERENCES, Mexico).
2012 CONICYT grant for Doctoral thesis support “Role of XBP1 on the regulation of the formation of
long-term memory”. Chile.
2012 Beca Chile for internships abroad for PhD students Qualified in the first place. Chile (WEILL CORNELL MEDICAL COLLEGE, USA).
2011 MECESUP grant for internships abroad for PhD students. Faculty of Medicine. University of Chile (HARVARD UNIVERSITY)
2009 – 2014 CONICYT Fellowship for PhD students.
TEACHING EXPERIENCE
2016-2019 Scientific Advisor. “Mentes Transformadoras”. Biomedical Neuroscience Institute (BNI).
2016 Co-adviser for undergraduate student from Macalester College – USA
2016 Co-adviser for Master student from Center for Research and Interdisciplinary (CRI) – France
2015-2016 Co-adviser for undergraduate course of Medicine, Faculty of Medicine, University of Chile.
2015-2017 Teaching for graduate course of Phisiology, Center of Biomedical Research, Universidad
Autónoma de Chile
2006-2007 Teaching assistant for undergraduate course of Laboratoy of Biochemistry, Faculty of Biological
Sciences, Pontifical Catholic University of Chile.
2005-2007 Teaching assistant for undergraduate course of Cell Biology, Faculty of Biological Sciences,
Pontifical Catholic University of Chile.
